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KMID : 0383820150780040463
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Tuberculosis and Respiratory Diseases
2015 Volume.78 No. 4 p.463 ~ p.468
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Pulmonary Langerhans Cell Histiocytosis in an Adult Male Presenting with Central Diabetes Insipidus and Diabetes Mellitus: A Case Report
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Choi Yeun-Seoung
Lim Jung-Soo
Kwon Woo-Cheol
Jung Soon-Hee
Park Il-Hwan
Lee Myoung-Kyu
Lee Won-Yeon
Yong Suk-Joong
Lee Seok-Jeong
Jung Ye-Ryung
Choi Ji-Won
Choi Ji-Sun
Jeong Joon-Taek
Yoo Jin-Sae
Kim Sang-Ha
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Abstract
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Pulmonary Langerhans cell histiocytosis is an uncommon diffuse cystic lung disease in adults. In rare cases, it can involve extrapulmonary organs and lead to endocrine abnormalities such as central diabetes insipidus. A 42-year-old man presented with polyphagia and polydipsia, as well as a dry cough and dyspnea on exertion. Magnetic resonance imaging of the hypothalamic-pituitary system failed to show the posterior pituitary, which is a typical finding in patients with central diabetes insipidus. This condition was confirmed by a water deprivation test, and the patient was also found to have type 2 diabetes mellitus. Computed tomographic scanning of the lungs revealed multiple, irregularly shaped cystic lesions and small nodules bilaterally, with sparing of the costophrenic angles. Lung biopsy through video-assisted thoracoscopic surgery revealed pulmonary Langerhans cell histiocytosis. On a follow-up visit, only 1 year after the patient had quit smoking, clinical and radiological improvement was significant. Here, we report an uncommon case of pulmonary Langerhans cell histiocytosis that simultaneously presented with diabetes insipidus and diabetes mellitus.
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KEYWORD
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Histiocytosis, Langerhans-Cell, Cystic Disease of Lung, Diabetes Insipidus, Diabetes Mellitus, Smoking Cessation
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